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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: PARP1 All Species: 22.42
Human Site: Y645 Identified Species: 49.33
UniProt: P09874 Number Species: 10
    Phosphosite Substitution
    Charge Score: 0
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens P09874 NP_001609.2 1014 113084 Y645 F Y P L E I D Y G Q D E E A V
Chimpanzee Pan troglodytes
Rhesus Macaque Macaca mulatta XP_001090751 1014 112883 Y645 F Y P L E I D Y G Q D E E A V
Dog Lupus familis
Cat Felis silvestris
Mouse Mus musculus P11103 1013 113081 Y644 F Y P L E I D Y G Q D E E A V
Rat Rattus norvegicus P27008 1014 112642 Y645 F Y P L E I D Y G Q D E E A V
Wallaby Macropus eugenll
Platypus Ornith. anatinus
Chicken Gallus gallus P26446 1011 113502 Y642 F Y P L E I D Y G Q D E E A V
Frog Xenopus laevis P31669 998 111108 Y628 F Y P L E I D Y G Q E E D V V
Zebra Danio Brachydanio rerio
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster P35875 994 113773 Q628 R M Y P I E I Q Y D D D Q K L
Honey Bee Apis mellifera
Nematode Worm Caenorhab. elegans Q9N4H4 945 107988 V596 L P K S V K E V V M S I F D V
Sea Urchin Strong. purpuratus
Poplar Tree Populus trichocarpa XP_002302058 996 111716 L626 K P G R F F P L D I D Y G V N
Maize Zea mays Q9ZSV1 980 110457 L610 Q P G R F Y P L D V D Y G V K
Rice Oryza sativa
Thale Cress Arabidopsis thaliana Q9ZP54 983 111214 L614 Q P G K F L P L D I D Y G V N
Baker's Yeast Sacchar. cerevisiae
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 N.A. 98.2 N.A. N.A. 91.9 91.7 N.A. N.A. 79.1 73 N.A. N.A. 41.7 N.A. 31.3 N.A.
Protein Similarity: 100 N.A. 99.1 N.A. N.A. 95.8 95.2 N.A. N.A. 88.6 84.2 N.A. N.A. 61.2 N.A. 51.5 N.A.
P-Site Identity: 100 N.A. 100 N.A. N.A. 100 100 N.A. N.A. 100 80 N.A. N.A. 6.6 N.A. 6.6 N.A.
P-Site Similarity: 100 N.A. 100 N.A. N.A. 100 100 N.A. N.A. 100 93.3 N.A. N.A. 26.6 N.A. 13.3 N.A.
Percent
Protein Identity: 41.1 39.3 N.A. 39.4 N.A. N.A.
Protein Similarity: 59.5 57.5 N.A. 58.3 N.A. N.A.
P-Site Identity: 6.6 6.6 N.A. 6.6 N.A. N.A.
P-Site Similarity: 6.6 6.6 N.A. 13.3 N.A. N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 0 0 0 0 0 0 0 0 0 0 0 0 46 0 % A
% Cys: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % C
% Asp: 0 0 0 0 0 0 55 0 28 10 82 10 10 10 0 % D
% Glu: 0 0 0 0 55 10 10 0 0 0 10 55 46 0 0 % E
% Phe: 55 0 0 0 28 10 0 0 0 0 0 0 10 0 0 % F
% Gly: 0 0 28 0 0 0 0 0 55 0 0 0 28 0 0 % G
% His: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % H
% Ile: 0 0 0 0 10 55 10 0 0 19 0 10 0 0 0 % I
% Lys: 10 0 10 10 0 10 0 0 0 0 0 0 0 10 10 % K
% Leu: 10 0 0 55 0 10 0 28 0 0 0 0 0 0 10 % L
% Met: 0 10 0 0 0 0 0 0 0 10 0 0 0 0 0 % M
% Asn: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 19 % N
% Pro: 0 37 55 10 0 0 28 0 0 0 0 0 0 0 0 % P
% Gln: 19 0 0 0 0 0 0 10 0 55 0 0 10 0 0 % Q
% Arg: 10 0 0 19 0 0 0 0 0 0 0 0 0 0 0 % R
% Ser: 0 0 0 10 0 0 0 0 0 0 10 0 0 0 0 % S
% Thr: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % T
% Val: 0 0 0 0 10 0 0 10 10 10 0 0 0 37 64 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 55 10 0 0 10 0 55 10 0 0 28 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _